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58 Respiratory Syncytial Virus In in vitro modeling of RSV infection carried out in cultures of primary normal human bronchial epithelial cells, N-acetylcysteine significantly inhibited viral infection, re-established the number of beating cells, restored the virus-induced decrease in expression of -tubulin and genes involved in ciliagenesis such as DNAI2 and FOXJ1, inhibited IL-13, MUC5AC, and GOB5 upregulation, inhibited ICAM1 expression, increased heme-oxygenase 1 expression which correlated with the restoration of cellular antioxidant capacity, and enhanced intracellular hydrogen peroxide and glutathione concentrations

This conclusion was confirmed by Sanchis et al

The amino acid that initially restricts the rate of protein synthesis is defined as the first limiting amino acid

10.1038/s41538-023-00245-8 91 RauS.GreggA.YaceczkoS.LimketkaiB