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Dopamine receptor antagonists (metoclopramide, prochlorperazine) These medications were originally developed as antiemetics, but clinical research has shown that they have migraine-specific effects independent of their anti-nausea properties

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For instance, reversed were increased number of inflammatory cells (38, 44-46) and the rise of leukotriene B4 (LTB4), thromboxane B2 (TXB2), and myeloperoxidase (MPO) in the serum and inflamed tissues (47-49)