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11 As described in that study, the diagnosis of malignant peripheral nerve sheath tumor is difficult and has historically suffered from a lack of entirely specific histological criteria

Given the presence of immature (less melanized) cells in many melanocytic neoplasias, it seems likely that specific underlying mutations (such as N-RAS , GNAQ , and B-RAF ) disrupt normal melanocytic development and result in accumulation of the nevomelanocytic cells that do not complete typical migration and differentiation

BCC located near the eyes, nose and ear can invade the orbital rim, nasal vault and middle ear respectively and may be larger than expected

Oral pigmentation may have a variety of causes, and differential diagnosis requires nodal analysis