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Additionally, inflammatory responses were modulated, with a reduction in pro-inflammatory cytokines and an increase in anti-inflammatory cytokines, compared to nave MSCs [73]

Similarly, bortezomib, a proteasome inhibitor, enhances ROS production, destabilizes mitochondrial membranes, and induces cytochrome c release in lung cancer cells (Ling et al

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Mascharak S, Griffin M, Talbott HE, Guo JL, Parker J, Morgan AG, Valencia C, Kuhnert MM, Li DJ, Liang NE, Kratofil RM, Daccache JA, Sidhu I, Davitt MF, Guardino N, Lu JM, Abbas DB, Deleon NMD, Lavin CV, Adem S, Khan A, Chen K, Henn D, Spielman A, Cotterell A, Akras D, Downer M, Tevlin R, Lorenz HP, Gurtner GC, Januszyk M, Naik S, Wan DC, Longaker MT