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Additional analytical techniques such as thinlayer chromatography and amino acid analysis confirm structural integrity and minimal contamination

Studies have shown that TSA downregulates extracellular matrix (ECM) gene transcription and collagen expression in dermal fibroblasts by inhibiting the TGF-/Smad and MAPK/ERK signaling pathways, contributing to its antifibrotic effects (60,61)

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Effect of electrical stimulation at auricular points combined with sound masking on the expression of CREB, BDNF and TrkB in the auditory cortex of tinnitus rats