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To make drugs and toxins less dangerous, the liver converts them from being fat-soluble (able to pass through cell membranes) to being water-soluble (able to be released through urine but much harder to enter cells)

doi: 10.1038/emm.2000.16 93

Schatten and Sun, 2015

A Bjorklund SB Dunnett 2007 Dopamine neuron systems in the brain: an update Trends Neurosci 30 5 194 202 GM Halliday PC Blumbergs RG Cotton WW Blessing LB Geffen 1990 Loss of brainstem serotonin- and substance P-containing neurons in Parkinsons disease Brain Res 510 1 104 107 Ojeda J, Avila A, Vidal PM (2021) Gut microbiota interaction with the Central Nervous System throughout life