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The reaction is more pronounced under certain specific conditions

Moreover, a knockout model of p300 in HCT116 cells exhibited decreased levels of multiple histone Kbhb sites, while p300 pharmacological inhibition led to reduced levels of both Kac (lysine acetylation) and Kbhb on H3K9, H3K18 and H4K8 sites in a dose-dependent manner (Huang et al., 2021)