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Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF 1 under normoxia Cell Death Discovery Cigarette smoke can reprogram cells in your airways, causing COPD to hang on after smoking ends JCI What are the mechanisms underlying vaping induced lung injury? Mitochondrial dysfunction is associated with Miro1 reduction in lung epithelial cells by cigarette smoke ScienceDirect

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