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Methylenedioxymethamphetamine: A potentially neurotoxic amphetamine analogue

Why selectivity matters Think of receptor biology as a lock-and-key system

doi: 10.1186/s12985-016-0567-6 472 Reyes-CastilloPAGonzlez-VzquezRTorres-MaravillaETelloMBermdez-HumarnLGMayorga-ReyesL

They synthesized polystyrene NPs targeting TfR, ganglioside GM1, or intercellular adhesion molecule-1 (ICAM-1), revealing disease-specific pathway modifications that impact brain delivery (Figure 10A)