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145 VanderzwalmenM.EatonL.MullenC.HenriquezF.CareyP.SnellgroveD.et al (2018)

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Insulin regulates insulin-like growth factor I mRNA in rat hepatocytes

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Furthermore, this study discovered that the inactivation of DHODH could sensitize GPX4 high cancer cells to ferroptosis inducers, and potentiate ferroptosis in GPX4 low cancer cells

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In VaD, an insufficient oxygen supply to the brain, reduced blood flow, and decreased intracellular oxygen partial pressure result in mitochondrial oxidative phosphorylation dysfunction, inhibition of protein synthesis, insufficient ATP production, and energy depletion, ultimately leading to sodium-potassium pump failure, calcium overloading, and disturbances in cytosolic ions (e.g., Ca 2+ , Na + , H + , ROS), which subsequently increase

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