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Yet ER client protein oxidation must be tightly regulated, because over-exuberant oxidation can cause the formation of disulfide-bonded protein aggregates, and can also prevent proteins from achieving the correct disulfide bonded configuration, for which the ability to reduce and reform (i.e., isomerize) disulfide bonds is needed

For a deeper look at abdominal discomfort specifically, including management strategies and dose-dependent pain patterns, see our stomach pains on reta research guide