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What we do know from the switching protocols published by various clinical practices is that starting low and titrating up works better than trying to jump to an "equivalent" dose

J Comp Neurol 212:3852 Mesulam M-M, Mufson EJ, Levey AI et al (1983) Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey

the May 2025 London Drugs Commission decriminalisation report and why a tolerance break comes first, not a peptide

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