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These agents act allosterically by binding a cryptic cavity in the SMURF1 HECT domains N-lobe, extending the H10 helix over the conserved glycine hinge (G634) and restricting catalytic motion between the N- and C-lobes to suppress SMURF1 activity

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Since one cigarette produces 1000 to 15000 g of PM (tar content of 1 to 15mg), a direct relationship with the PM concentration in Beijing air pollution can be made