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1 Introduction The term metabolism originates from the ancient Greek word (metabol), which entered scientific nomenclature in the late 19th century to describe the totality of biochemical transformations through which cellular components in the cytosol and nucleus undergo renewal, modification, or preparation for excretion (Li et al., 2019)

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After human FMT or co-housing introducing Desulfovibrionales to GS-R mice, these mice had a similar bile acid profile with GS-S mice and hepatic Cyp7a1 expression was reduced accordingly

The most common bleed was melena 21/26 (80.7), followed by hematemesis in 3/26(11.5%) and the remaining had hemoglobin drop