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In addition, genetically modified cancer cell lines in which FSP1 is knocked out (MDA-436-MB FSP1 KO, NCl-H1437 FSP1 KO, U-373 FSP1 KO, MDA-MB-435S FSP1 KO, A549 FSP1 KO and SW620 FSP1 KO) as well as cell lines with lentiviral overexpression of FSP1 (IMR5/75 hFSP1, 786-O hFSP1, LOX-IMVI hFSP1 and HLF hFSP1) are shown

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Honokiol also inhibited caspase-1 activation, and apoptosis speck-like protein oligomerization, suggesting dual inhibition of NLRP3 inflammasome priming and activation processes through the modulation of the SLC3A2/L-leucine/mTORC1/NLRP3 pathways [490]