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Synaptic mitochondria mature earlier (Almeida et al., 1) and in the TCA cycle (Malik et al., A three fourfold increase in cycle flux has been shown by 13 C-NMR in rat brain cortex by Chowdhury et al

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2.8 The impact of natural products on Alzheimers disease AD, as a multifaceted neurodegenerative disorder, involves a complex array of pathological processes, including amyloid-beta (A) plaque formation, tau protein hyperphosphorylation, oxidative stress, mitochondrial dysfunction, and chronic neuroinflammation