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The use of food supplements, including those with antioxidant activity (multivitamins, vitamin B6), was associated with increased risk of total mortality [57]

(2012) Spinal metastasis in thyroid cancer

Discussion Glioblastoma is characterized with high cell proliferation and neovascularization leading to tumor infiltration reaching crucial structures in the brain

During oxidative stress, NRF2 monitors the cellular response to oxidative stress by mediating detoxification through dissociation from the cytoplasmic inhibitor Keap1, which then translocates to the nucleus and activates the NRF2 transcriptional gene to provide cellular protection against oxidative stress (Hayes and McMahon, 2009)