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Reactive oxygen species are natural byproducts of cellular metabolism and require ongoing regulation by antioxidant systems to help maintain balance and limit oxidative stress

Its about deep health signals: - Sleep fragmentation - Elevated insulin and cortisol - Sedentary behavior - Artificial light at night - Chronic under-eating or over-restricting carbs and proteins - Shallow breathing, low VO2max, and poor mitochondrial turnover All of these suppress endogenous GH pulses, regardless of chronological age

DECLARATIONS Authors contributions Developed the model, ran simulations and analyses, interpreted the findings, and contributed to the writing and editing of the manuscript: Cruikshank A, Reed MC, Nijhout HF Availability of data and materials Computer models and codes used in this paper can be obtained from the authors by request

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