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The TME consists of multiple elements: in addition to epithelial, stromal, and immune cells, recent interest has been focused on cancer-associated fibroblasts (CAF) and adipocytes

It can be easily treated with a course of vitamin B12 injections, but if left untreated, the condition can become permanent

Specific Gravity (= Relative Density) - SG - is a dimensionless unit defined as the ratio of the density of a substance to the density of a reference substance - at a specified temperature and pressure, and can be expressed as SG = substance / reference (1) where SG = Specific Gravity of the substance substance = density of the fluid or substance (kg/m 3 ) reference = density of the reference (kg/m 3 ) It is most common to use the density of water at 4 o C (39 o F) as a reference since water at this point has its highest density of 1000 kg/m 3 or 1.940 sl/ft 3

The metabolite content was then standardised, after which a hierarchical clustering heat map was constructed