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These decreases in GSAAT content cannot be explained by reduced transcriptional activity of the corresponding GSA1 and GSA2 genes ( Figure 4G )

MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2,3-dideoxycytidine and 9-(2-phosphonylmethoxyethyl)adenine