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does not contain allergens

Furthermore, TMAO increased aortic plaque area and altered bile acid composition in male ApoE (-/-) mice, accelerating aortic lesions by modifying bile acid profiles, activating FXR and small heterodimer partner, and inhibiting bile acid synthesis (136)

This has not been examined in subgroup analyses

However, the prospective studies that have examined the associations between vitamin C intake and the risk of cardiovascular disease have produced conflicting results, and most clinical trials have not found conclusive evidence that vitamin C supplements can protect against cardiovascular disease