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Mechanistically, Tagitinin C induces oxidative stress and endoplasmic reticulum (ER) stress, leading to Nrf2 nuclear translocation and subsequent expression of its downstream target, HO-1

Subsequent studies, however, have shown less (57) to no association (58), associations only with certain types of dairy (e.g., milk) (59), or differing associations by fat-content of milk such as positive association with low-fat milk (58) and inverse association with high-fat milk (58)

Moreover, the use of NAC and knockdown of either p53 or seven-in-absentia homolog 1 prevented the inhibitory effects of H 2 O 2 87