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Data availability The authors declare that all data supporting the findings of this study are provided in the Manuscript and its Supplementary Information/Source Data files

Plasma PGA levels, reflecting glutathione (GSH) metabolic homeostasis, were analysed in three groups represented by: healthy controls with the wild-type TTR genotype, asymptomatic carriers of the TTR-V30M mutation, and symptomatic patients with TTR-V30M amyloidosis

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whether supplementation earlier than this is beneficial is unknown