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Glutamine is an important energy source for tumor cells, and metabolic reprogramming of glutamine signaling contributes to immune evasion in the tumor microenvironment via limiting immune cell glutamine utilization and regulating tumor PD-L1 expression ( There is also emerging evidence for the role of asparagine and asparagine synthetase (ASNS) in immune activation in lung cancer

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[DOI] [PubMed] [Google Scholar] 74.Santini Z.I., Koyanagi A., Tyrovolas S., Haro J.M