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Semaglutide is a glucagon-like peptide-1 agonist that works on the GLP-1 receptors in the body to reduce appetite by delaying gastric emptying

At first glance, this may seem an appropriate and straightforward way to quantify the treatment effect, but there are several reasons why the placebo-adjusted effect sizes of a drug in RCTs do not necessarily indicate the effect sizes that are achieved in real-life patient management