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doi: 10.3389/fimmu.2018.00268 Received 21 November 2017 Accepted 30 January 2018 Published 19 February 2018 Volume 9 - 2018 Edited by Tobias Schuerholz, Universittsmedizin Rostock, Germany Reviewed by Sergio Ivn Valds-Ferrer, Instituto Nacional de Ciencias Mdicas y Nutricin Salvador Zubirn, Mexico

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Results: Over an average follow-up period of 23.0 years, the MAFLD group did not exhibit a significant increase in all-cause mortality (adjusted hazard ratio [95% confidence interval], 1.07 [0.99-1.16], P =0.100), cancer mortality (1.08 [0.86-1.36], P =0.508), or cardiovascular mortality (0.89 [0.78-1.02], P =0.084) compared to the MA without fatty liver group

Since mRNA is not very stable, these constructs include modified nucleosides to prevent degradation