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The second most abundant cannabinoid, cannabidiol (CBD) constitutes up to 40% of cannabis extracts.38 Recently, CBD has been deemed as a safe and efficacious treatment option for schizophrenia.38 Comparable to typical neuroleptics and unlike tetrahydrocannabinol (THC), CBD has been found to induce proneurocognitive, anxiolytic, and antipsychotic effects.38 A recent functional MRI study showed that THC and CBD exerted opposite effects on activation in the striatum, hippocampus, amygdala, superior temporal cortex, and occipital cortex.39 The researchers also found that pretreatment with CBD averted the induction of psychotogenic effects typically produced by THC

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