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In addition for lungs, one lobe was stored in RNA Later (Ambion, ThermoFisher Scientific, Illkirch, France) for transcriptomic analyses, posterior lobes were fixed with paraformaldehyde (PFA 4%, Labonord, Villeneuve dAscq, France) for histopathological analyses, and another lobe was frozen in liquid nitrogen and then stored at 80 C until further analyses

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5 for results without 10% trimming and Supplementary Table 8 for observed RR data and alternative exposures across studies for the remaining 2-star pairs