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Investigation of chronic GAC1 treatment (20 mg/kg) demonstrated significant reductions in pulmonary inflammation and airway neutrophilia, and inhibited TNF-, IL-4, and IL-5 levels in vivo [109]

FIGURE 4 3.4 Nitazoxanide reduced apoptosis in rats with MTX-hepatotoxicity MTX significantly induced hepatic apoptosis as demonstrated by increased proapoptotic markers, Bax level, and caspase-3 activity (Figures 5A, D) while reduced antiapoptotic Bcl-2 level (Figure 5B) and increased Bax/Bcl-2 ratio (Figure 5C) compared to CTRL group

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Duration of use for cardiovascular goals typically follows the standard 4-6 week protocol, though some users extend to 8 weeks for chronic conditions