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Cummins N, Tweedie A, Zuryn S, Bertran-Gonzalez J, Gtz J (2019) Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria

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[15] [16] This alternative route may be particularly relevant when endothelial function is compromised

Mechanistically, metformin enhances the expression and activity of SIRT1 and subsequently downregulates TLR4, p-NF-B, IL-1 and iNOS (the makers of proinflammatory M2 macrophages) and upregulates Arg1 (the maker of anti-inflammatory M1 macrophages) expressions to increase M2 macrophage polarization and inhibit M2 macrophage polarization (Liu H