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Kidney organoids derived from human pluripotent stem cells (hPSCs) contain segmented structures with podocytes, proximal tubules, and distal tubules in nephron-like arrangements and can recapitulate kidney development 15,16

Study limitations Oral NAC is associated with gastrointestinal discomfort, nausea, and diarrhea, but these symptoms are generally mild and occur at similar rates in placebo groups, indicating that NAC is well-tolerated and safe for chronic use [108]