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An additional insult or pathogenic factor, often referred to in the literature as the second hit, is required to trigger the progression from simple steatosis to steatohepatitis (MASH), characterized by hepatocellular injury, inflammation, and varying degrees of fibrosis [32]

After the samples were dehydrated, embedded, and stained, images were acquired using a transmission electron microscope (Hitachi HT7700, Tokyo, Japan)

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This inconsistency in efficacy assessment may stem from differences in disease stage, statin type, and treatment timing, highlighting the uncertainty regarding its clinical benefits