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Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer

Communication between the individual NVU components is key for its correct function

Oxidative depletion of BH 4 as a cause of eNOS uncoupling and endothelial dysfunction has been described in vivo, in the aortas of mice with deoxycorticosterone acetate-salt (DOCA-salt) hypertension [29], spontaneously hypertensive mice and rats [97, 98], apolipoprotein E (poE)-deficient mice [99], or aged mice and rats [33, 100]