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Previous studies have shown that a small molecule called Ras Lethal 3 ((1S,3R)-RSL3,(RSL3)) can pharmacologically inhibit GPX4 in skin and soft tissue cancer models in vitro and leads to induction of ferroptosis 10,11

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It has been postulated that brewed unfiltered coffee contains much more antioxidant substances than ready-to-drink coffee used in our study as well as paper-filtered coffee, 23 possibly resulting in a larger content of antioxidant substances that were absorbed into the systemic circulation following oral administration, and hence a higher total antioxidant status in the plasma