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Hence, Chen et al

Juvenile separation stress induces rapid region- and layer-specific changes in S100ss- and glial fibrillary acidic protein-immunoreactivity in astrocytes of the rodent medial prefrontal cortex

But it can lead to Adrenal Fatigue Syndrome (AFS)

used IL-1 receptor antagonist to antagonize IL-1, which reversed BBB damage and cognitive impairment after brain oxidative damage, confirming that IL-1 is an important factor mediating cognitive impairment in sepsis (Mina et al., 2014)