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JCI Tobacco smoking induces metabolic reprogramming of renal cell carcinoma 2 Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: Formation of a lung carcinogen precursor PNAS File:Nicotine metabolism.png Wikipedia Figure 5.3, Metabolism of six carcinogens in tobacco smoke that produce DNA adducts identified in the lungs of smokers How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking Attributable

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