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The most common vitamin B12 deficiency symptoms are: Fatigue Weakness Loss of appetite Weight loss Numbness and tingling in the hands and feet Soreness of the mouth or tongue A pale yellow tinge to your skin Difficulty maintaining balance Disturbed vision Depression Confusion Poor short-term memory A severe vitamin B12 deficiency can cause megaloblastic anemia, also known as vitamin B12 deficiency anemia, where red blood cells are not produced properly and are larger than normal

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Further explorative studies in murine models involving ligation (the surgical blockage of coronary arteries) have hinted that TB-500 might elevate the levels of integrin-linked kinase (ILK) and protein kinase B (Akt)