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Description

Apolipoprotein E2-Christchurch (136 Arg----Ser)

Lowering serum AGEs levels through dietary modifications or AGE inhibitors (239), as well as utilizing RAGE antagonists (228, 234), significantly improves macrophage infiltration, reduces inflammation, and alleviates kidney damage

Pap1 nuclear localisation and recruitment to promoters of oxidoreductase and membrane transporter genes is increased, causing increased efflux activity