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31 The molecular docking studies conducted on bioactive metabolites derived from Burkholderia stagnalis revealed promising interactions with the GST protein of E

multocida resulting in the emergence of multidrug-resistant (MDR) pathogens that are known to have a serious threat to the treatment and control of infectious diseases in both animals and humans (1115)

In contrast, rapid and excessive glucose supplementation may lead to metabolic overload, enhance glycolysis, and result in abnormal lactate reaccumulation, exacerbating metabolic disturbances (Xiong et al., 2024)

The association between MMP-9, p38 kinase and MCLK is likely mediated by the pro-inflammatory transcription factor NF-kB, as silencing of the p38 kinase prevented MMP-9 from activating NF-kB p65 and increasing MLCK expression [91]