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A network linking compounds, targets, pathways, and diseases (C-T-P-D) was created by compiling information on the relevant compounds, targets, and associated pathways (Supplementary Fig

treated human THP-1 macrophage cells, human WI38 fibroblast cells, and mouse fibroblast cells with PPAR agonists such as fenofibrate, bezafibrate, and gemfibrozil, and observed increased ABCA1 mRNA and protein levels

Lastly, optimization of variables such as temperature, extraction time, pressure, and solvent-to-solid ratio is critical yet challenging, as these parameters profoundly influence extraction efficiency and compound stability (66)

This negative feedback regulation is crucial for maintaining cellular homeostasis and preventing uncontrolled cell proliferation