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Description

DOI: 10.1007/s00018-003-3206-5 51

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When Hedgehog binds to PTCH, activated Smo transmits signals through Gli, Sufu, and Kif7, resulting in the generation of the Gli-activated form (GliA), which translocates to the nucleus and leads to transcriptional activation of Hh target genes

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Moreover, the mammalian target of rapamycin (mTOR) complex family proteins regulates ferroptosis by manipulating SLC7A11 (Xu et al., 2021)

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TREM2 lipid sensing sustains the microglial response in an Alzheimers disease model

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