gold standard test for glutathione levels rbc Index Erythrocyte glutathione (GSH) plotted as

D.DavidianJ

10.1038/nrm3270 Nat

PD is characterized by dopaminergic neuron loss and -synuclein aggregation, exacerbated by GSH depletion in the substantia nigra (74)

Although the presence of ferroptosis was first demonstrated in cancer, given the increasing number of associated studies, ferroptosis has been shown to fulfill an important role within the nervous system (11,2630), and common neurological disorders, including ischemic stroke (31), Alzheimer's disease (32) and Parkinson's disease (33), have been found to be closely associated with ferroptosis, the latter two being common neurodegenerative disorders wherein the molecular mechanism is mainly concerned with an aggregation of iron in the hippocampal region of the brain or in dense areas of the substantia nigra, and these responses have been shown to be inhibited by the ferroptosis inhibitor, ferrostatin-1 (Fer-1) (3436)