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The pooled SMDs for overall urgency assessment between treatments versus the control group was -0.40 (95% CI: -0.75, -0.05)

This is the window that the Finkley 2005 trial captured, and the Carey/Pickart ultrasound work confirmed at the structural level: an average 28% increase in collagen density, with top responders at 51%

[DOI] [PubMed] [Google Scholar] 147.Ricci S., Businaro R., Ippoliti F., Lo Vasco V.R., Massoni F., Onofri E., Troili G.M., Pontecorvi V., Morelli M., Rapp Ricciardi M., et al

79 80 Polynucleotides work at the cellular level to jump-start repair, with clinical trials showing better elasticity, fewer wrinkles, and smoother, firmer skin