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This neuroimmune-tumor connection is also paradoxical as links also exists between chronic inflammation and tumorigenesis, with glioma cells producing pro-inflammatory cytokines, chemokines, and growth factors that create an inflammation-enriched TME (65, 66)

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DOI: 10.1016/j.anireprosci.2013.03.012 24

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Vitamin C is one of the most critical cofactors

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Pathogenesis of diabetes is then characterized by a potent oxidative stress, as increased levels of reactive oxygen species (ROS) are present (194)

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