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Gold nanoparticles inhibit osteoclast formation through antioxidant effects, achieving a significant reduction

The nuclear factor erythroid-2 related factor 2 (Nrf2)-HECT and RLD domain containing E3 ubiquitin protein ligase 2 (HERC2) axis has been shown to modulate cellular iron homeostasis and ferroptosis sensitivity through vesicle associated membrane protein 8 (VAMP8) regulation ( 3.2 Morphological characteristics of ferroptotic cells Ferroptosis manifests distinct morphological alterations that differentiate it from other cell death modalities

As for using ALA topically, we have to say that its role and effects seem to be less direct than with LA

Results were comparable with MCF7-vector cells (Fig 2A (iv to vi) compared with 2B), as expected for a specific PLA reaction