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Under chronic stress, neurons have impaired synaptic number and function as well as diminished plasticity, which increases susceptibility to depression [44]

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Interstitial space of the tissues comprises the intercellular, fluid, mucopolysaccharide matrix among the reticular fibers of organ tissues, elastic fibers in the walls of vessels or chambers, collagen fibers of fibrous tissues, or that same matrix within connective tissue ensheathing muscle cells or in the lacunae of bone