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Conclusions Although there is plenty of data on the anabolic potential of GH, IGF-I, and insulin and on their safety and efficacy at physiologic doses, most of this information comes from their therapeutic use in other settings (AGHD, diabetes), or from pathological disorders characterized by hormone hypersecretion (acromegaly, insulinoma)

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Activation of NF-B, for instance, promotes the transcription of genes encoding a wide array of pro-inflammatory mediators, including cytokines (e.g., TNF-, IL-1, IL-6, IL-18) and chemokines (e.g., MCP-1, IL-8) (Liu et al., 2020)

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