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495 Initial studies of the role of GDI1 were focused on neurones

Several biological DMARDs have recently emerged including TNF-inhibitor (Amjevita, Renflexis, Erelzi, Cyltezo, Imradl), anti-CD20 antibody (Truxima, Rixathon), IL-6 receptor antibody (Kevzara), RANKL antibody (Pralia), and JAK inhibitor (Olumiant)

elegans model of PD with RNAi-mediated bcat -1 knockdown, metformin reduced mitochondrial respiration, rescued neuronal viability, and significantly improved motor function, possibly through inhibiting complex I [156]