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Critically, the cytokines we will assay using the described DBS protocol have been validated against plasma obtained through a venipuncture from the same individuals collected at the same time using standard protocols from the field ( R 2 = 0.82

Proteins were analysed by western blotting using the respective antibodies presented in Supplementary Table 2 and either LLC Western Lightning Plus ECL (Revvity Health Sciences) for chemiluminescent signal or a Li-Cor Odyssey CLx for fluorescent signal

Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were both implemented by KOBAS software (version: 2.1.1) for annotated genes, and the cutoff value of the corrected p -value at 0.05 aimed at assessing the statistical significance of enrichment

GuentherALSchmidtSILaatschHFotsoSNessHRessmeyerARet al