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The impact of the microbiome extends beyond mere digestion, permeating into complex physiological processes, influencing immune system modulation, and perhaps aiding in the growth of the CNS and brain ( Table 3 ) ( Figure 5 ) and exhibits rapid responses to system alterations due to the interplay between genetic and environmental factors

Mol Ther Oncolytics 20:569582 Wang Q, Dai X, Xiang X, Xu Z, Su S, Wei D, Zheng T, Shang EX, Qian D, Duan JA (2021b) A natural product of acteoside ameliorate kidney injury in diabetes db/db mice and HK-2 cells via regulating NADPH/oxidase-TGF-/Smad signaling pathway

A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/beta-catenin signaling

Systemic activity extends the peptide's benefit beyond isolated tendon repair to the broader musculoskeletal environment of the injured region